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The recommended treatment for Grade 3 cells (also known as high-grade squamous intraepithelial lesions or HSIL) found on a Pap smear is LEEP (Loop Electrosurgical Excision Procedure) excision. HSIL indicates a significant risk of progression to cervical cancer, which necessitates a more definitive approach to treatment.

LEEP is a minimally invasive procedure that allows for the removal of abnormal cervical tissue for diagnosis and treatment. By utilizing an electrically charged wire loop, it effectively excises the area containing the abnormal cells while allowing for simultaneous examination of the tissue to ensure that it has been adequately treated.

This approach is essential because it prevents potential progression to cervical cancer, addressing the high-risk status associated with Grade 3 findings. Other treatments, such as observation, are not appropriate for HSIL due to their potential to miss an underlying malignancy. Cryotherapy may be used for lower-grade lesions but is not recommended for higher-grade lesions where excisional procedures are required. Hormonal therapy has no role in the management of abnormal cervical cytology findings.